August 13, 2009
IBM Almaden Research Center (map), Auditorium A

more info and program will be posted soon

Thursday, April 17th 1:00-2:15pm

Clark S362
Henk P. Haagsman, Ph.D. Professor, Department of Infectious Diseases and Immunology Faculty of Veterinary Medicine, Utrecht University

In mammals, cathelicidins have shown to possess potent broad-range antimicrobial activity as well as immunomodulatory activities. Not much is known about avian collectins. Therefore, we investigated chicken cathelicidin microbicidal activities and the localization of chicken cathelicidin chicken myeloid antimicrobial peptide 27 (CMAP27) in healthy and Salmonella-challenged chicken broilers. Using immunohistochemistry, CMAP27 was shown to be abundantly present in heterophils, and absent in intestinal epithelial cells. Considerable infiltration of CMAP27-positive heterophils was observed in the jejunum of Salmonella enteriditis-challenged broilers within 8 h p.i. LPS- and phorbol ester-stimulated heterophils were shown to release mature CMAP27 peptide in a time-dependent way. Synthetic CMAP27 peptide showed potent bactericidal and fungicidal activity against all tested strains, including chicken-specific Salmonella isolates. These results underscore the importance of avian heterophils as a first line of defence against invading pathogens and implicate that via heterophil-mediated release, cathelicidins may greatly contribute to avian innate immunity

Location: J2-609, IBM ARC

Speaker: Antonio A. Garcia, Professor

Harrington Department of Bioengineering, Arizonia State University

Type: Invited Talk

Dr. Garcia is the Associate Director of the Hispanic Research Center and Professor of Bioengineering in the Ira A. Fulton School of Engineering at Arizona State University where he has focused on designing and characterizing surfaces and colloids for diagnostic devices and biomolecule separation.

B.S. Chemical Engineering - Rutgers University, New Brunswick 1981

Contact Info:
Office Location: ISTB1 240

Phone: (480) 965-8798

Email: tony.garcia@asu.edu

Download Abstract .pdf

Please contact Zhenan Bao (3-2419, zbao@stanford.edu) if you are interested in meeting him.

Speaker: Dr. Yen Wei, Herman B. Wagner Professor of Chemistry, Department of Chemistry, Drexel University, Philadelphia, PA 19104 (weiyen@drexel.edu).

ABSTRACT: We have developed a novel, biocompatible nonsurfactant-templating pathway to nanoporous metal oxides with high surface area (~1000 m2/g) and pore volume (~1.0 cm3/g) as well as pore size in the range of 2-15 nm with narrow pore size distribution[1]. The nonsurfactant molecules, such as glucose, dibenzoyl tartaric acid, fructose, cyclodextrins, urea, glycerol, etc., are used as templates to direct the mesostructure formation in sol-gel reactions. The entire preparation can be performed at room temperature and neutral pH. Such a novel materials platform has enabled us to encapsulate a variety of bioactive substances including enzymes, proteins, nucleic acids and therapeutic agents directly in nanoporous host materials for biocatalysis, biosensor, drug release, nanobioreactor, and enzyme therapy applications [2]. This also provides a new tool to study protein behavior in confined space, including protein folding and protein-protein interactions as well as protein aggregations as in Alzheimer’s and Parkinson’s diseases. The nanoporous materials have also been employed as fillers for the synthesis of nanocomposite and dental materials. In addition, electroactive materials have been used as scaffolds for neural, cardiac and stem cell tissue engineering [3].

[1] Wei, et al. Adv. Mater. 3:313 (1998) and 12:1448 (2000); US Pat. 6,696,258 (2004).

[2] Wei, et al. J. Nanosci. Nanotech. 1:83 (2001); Nano Lett. 6:1042 (2006).

[3] Huang, et al. Biomaterials, 28:1741 (2007).
(more…)

Ann Goffin (Fuller Group)
Interfacial flow processing of biological molecules

Masaki Yanagioka (Frank Group)
Morphological and mechanical characterization and particle filled hydrogels

Location: The colloquium will be in the Gazebo.

Chaitan Khosla
–
Chaitan Khosla
Professor,
Departments of Chemistry, Chemical Engineering and (by courtesy) Biochemistry
Stanford University
Stanford CA 94305
Email: khosla@stanford.edu