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Curtis W. Frank

CPIMA Director, Professor, Chemical Engineering, Stanford University


Telephone: (650) 723-4573
Fax: (650) 723-9780
Email: | Web site

Curtis W. Frank Sr. Professor of Chemical Engineering and (by courtesy) of Materials Science and Engineering and of Chemistry;

Polymer Physics and Molecular Assemblies, Stanford University, Stanford, CA. B.A. with High Distinction, Chemical Engineering, 1967, University of Minnesota; M.S., Chemical Engineering, 1969, Ph.D., Chemical Engineering, 1972, University of Illinois, Urbana, IL.  

Frank is the 1990 Winner of the C.M.A. Stine Award of the Division of Materials Science and Engineering of the American Institute of Chemical Engineers; 1993 Chairman of Division of Polymer Chemistry of the American Chemical Society; other positions in A.C.S. He is a Fellow of the American Physical Society. He is on the Editorial Boards of Polymer and Polymers for Advanced Technologies.

Frank explores the molecular structure of high polymers and small amphiphilic molecules capable of self-organization through photostationary and transient fluorescence, Fourier transform infrared spectroscopy, surface plasmon spectroscopy, and optical and atomic force microscopy. He studies polymers, fatty acids, surface coupling agents, dendrimers and liquid crystals at the air/water interface and in constrained geometries on solid substrates; organic/inorganic nanocomposites; and applications of polymers in microelectronics. He is the Principal Investigator of the National Science Foundation Materials Research Science and Engineering Center on Polymer Interfaces and Macromolecular Assemblies (CPIMA).


Selected Publications:

  1. Mason, A. F., Lohmeijer, B. G. G., Li, H., Pratt, R. C., Liao, Q., Frank, C. W., Kingsbury, K., Waymouth, R. M., Hedrick J. L.; "Organocatalytic Polymerization of Ethylene Oxide and the Controlled Synthesis of Peo-Based Hydrogel Networks." Polymer Preprints ( American Chemical Society, Division of Polymer Chemistry), 47, 2, 99-100, 2006.
  2. Malkoch, M., Vestber, R., Gupta, N., Mespouille, L., Dubois, G., Mason, A. F. Hedrick, J. L., Liao, Q., Frank, C. W., Kingsbury, D., Hawker, C. J.; "Synthesis of Well-Defined Hydrogel Networks Using Click Chemistry". Chem. Commun., 2774-2776, 2006.
  3. Muir, B.V.O., Corten, C., Kuckling, D., Kasry, A., Knoll, W., Frank, C.W.; "Fabrication of Tunable Diffraction Gratings Based on Thermoresponsive NIPAAm Hydrogels for Grating Coupled Surface Plasmon Resonance." Polymer Preprints (American Chemical Society, Division of Polymer Chemistry), 47, 2, 1082, 2006.
  4. Rocha-Mendoza, I., Yankelevich, D. R.,Wang, M., Bratton, C., Reiser, K. M., Frank, C. W., Knoesen, A.; "Achiral and Chiral Sum Frequency Vibrational Spectroscopy of Collagen Fibrils". CLEO/QELS, JTuD52, 2006.
  5. Hwang, L.Y., Götz, H., Hawker, C.J., Frank, C.W.; “Glyco-acrylate Copolymers for Bilayer Tethering on Benzophenone-modified Substrates”. Colloids and Surfaces B: Biointerfaces, 54, 127-135, 2007.

    Rocha-Mendoza, I., Yankelevich, D. R., Wang, M., Reiser, K. M., Frank, C. W., Knoesen A.; “Sum Frequency Vibrational Spectroscopy the Molecular Origins of the Optical Second-Order Nonlinearity of Collagen”. Biophysical Journal, 93, 12, 4433-4444, 2007.

    Nederberg, F., Trang, V., Pratt, R.C., Mason, A.F., Frank, C.W., Waymouth, R.M., Hedrick, J.L.; “New Ground for Organic Catalysis: A Ring-Opening Polymerization Approach to Hydrogels”. Biomacromolecules, 8, 3294-3297, 2007.

    Choi, J., Lohmeijer, B.G.G., Pratt, R.C., Dubois, G., Hermans, T.M., Frommer, J.; Nederberg, F.; Kim, H.C.; Waymouth, R.M.; Hedrick, J.L. "Expanding the Scope of Nanostuctures Possible from Block Copolymers: Role of Selective Deposition Solvent". Polymer Preprints (American Chemical Society, Division of Polymer Chemistry), 48, 884-885, 2007.

    Culkin, D. A., Jeong, W., Csihony, S., Gomez, E. D., Hedrick, J. L., Balsara, N. P., Waymouth, R. M.; “Zwitterionic Polymerization of Lactide to Cyclic Poly(lactide)s by using N-Heterocyclic Carbene Organocatalysts”. Angew. Chem., Int. Ed., 46, 2627-2630, 2007.

    Coulembier, O., Kiesewetter, M., Mason, A., Dubois, P., Hedrick, J. L., Waymouth, R. M.; “A Distinctive Organocatalytic Approach to Macromolecular Architectures”, Angew. Chem., Int. Ed., 46, 4719-4721, 2007.

    Jeong, W., Hedrick, J. L., Waymouth, R. M.; "Organic Spirocyclic Initiators for the Ring-Expansion Polymerization of -Lactones". J. Am. Chem. Soc., 129, 8414-8415, 2007.

    Coulembier, O., Delva, X., Hedrick, J.L., Waymouth, R. M., Dubois, P.; "Synthesis of Biomimetic Poly(hydroxybutyrate): Alkoxy- and Carboxytriazolines as Latent Ionic Initiator". Macromolecules, 40(24), 8560-856, 2007.

    Zhang, L., Nederberg, F., Messman, J.M., Pratt, R. C., Hedrick, J.L., Wade, C.G.; "Organocatalytic Stereoselective Ring-Opening Polymerization of Lactide with Dimeric Phosphazene Bases". J. Am. Chem. Soc., 129, 12610-12611, 2007

    Scholten, M D., Hedrick, J.L., Waymouth, R.M.; "Group Transfer Polymerization of Acrylates and Methacrylates Using N-Hetereocyclic Carbene Catalysts". Polymer Preprints (American Chemical Society, Division of Polymer Chemistry), 48, 167-168, 2007.

    Jeong, W., Shin, E. J., Culkin, D. A., Hedrick, J.L., Waymouth, R.M.; "N-Heterocyclic Carbene-Mediated Zwitterionic Polymerization: An Expedient Organocatalytic Route to Cyclic Polyesters". PMSE Preprints, 97, 82-83, 2007

    Wang, W., Knoesen, A.; “Rotation and Scale Invariant Texture Features Based on Spectral Moment Invariants”. Journal of the Optical Society of America A, 24, 9, 2550-2557, 2007.

    Wang, M., Reiser, K. M., Knoesen, A.; “Spectral Moment Invariant Analysis of Disorder in Polarization-Modulated Second Harmonic Generation Images Obtained from Collagen Assemblies”. Journal of the Optical Society of America A, 24, 11, 3573-3586, 2007.

    Kim, S.H., Nederberg, F., Pratt, R.C., Choi, J., Zhang, L., Wade, C.G., Waymouth, R.M., Hedrick, J.L.; "Effect of Stereochemistry and Sterecomplexation of Polylactides on Organosilicate Nanostructure". PMSE Preprints, 97, 221-222, 2007.

    Nederberg, F., Lohmeijer, B.G.G., Leibfarth, F.; Pratt, R. C.; Choi, J.; Dove, A.P., Waymouth, R. M., Hedrick, J. L.; "Organocatalytic Ring Opening Polymerization of Trimethylene Carbonate" Biomacromolecules, 8, 153-160, 2007.

    Zhang, L., Nederberg, F., Pratt, R. C, Waymouth, R. M., Hedrick, J. L., Wade, C. G.; "Phosphazene Bases: A New Category of Organocatalysts for the Living Ring-Opening Polymerization of Cyclic Esters". Macromolecules, 40, 4154-4158, 2007.

    Kamber, N.E., Jeong, W., Waymouth, R.M., Pratt, R.C., Lohmeijer, B.G.G., Hedrick, J. L.; "Organocatalytic Ring-Opening Polymerization". Chem. Rev., 107, 5813-5840, 2007.

    Pratt, R.C., Nederberg, F., Lohmeijer, B.G.G., Waymouth, R.M., Hedrick, J.L.; "Fully Degradable Functionalized Polymers: A Versatile Approach Using Ring-Opening Polymerization of Cyclic Carbonates". PMSE Preprints, 96, 204-205, 2007.


    Leibfarth, F.A., Lohmeijer, B.G.G., Nederberg, F., Pratt, R.C., Logan, J.W.; Waymouth, R.M.; Hedrick, J.L.; "Organocatalytic Ring Opening Polymerization of Cyclic Monomers: Mechanistic and Synthetic Studies". Polymer Preprints (American Chemical Society, Division of Polymer Chemistry), 48, 984-985, 2007.

    Waymouth, R.M., Hedrick, J.L., Nederberg, F., Pratt, R.C., Lohmeijer, B.G.G., Culkin, D.A., Coulembier, O., Kamber, N E., Jeong, W., Kiesewetter, M.K., Shin, E.J.; "Polyesters from Renewable Resources: Organocatalytic Strategies for Controlled Polymerization Reactions". Polymer Preprints (American Chemical Society, Division of Polymer Chemistry), 48, 812-813, 2007.

    Zhang, L., Nederberg, F., Pratt, R. C., Waymouth, R.M., Hedrick, J.L., Wade, C.G.; "Phosphazene Bases for the Organocatalytic Living Ring-Opening Polymerization of Cyclic Esters". Polymer Preprints (American Chemical Society, Division of Polymer Chemistry), 48, 875-876, 2007.

    Nederberg, F.; Pratt, R. C.; Mason, A. F.; Waymouth, R. M.; Hedrick, J. L. "An Organocatalytic Route to Functional and Biodegradable Hydrogels" Polymer Preprints (American Chemical Society, Division of Polymer Chemistry) 2007, 48, 907-908.

    Pratt, R.C., Nederberg, F., Waymouth, R.M., Hedrick, J.L.; "Functionalizing Polyesters and Polycarbonates: Covalent Tagging of Alcohols for Ring-Opening Polymerization". Polymer Preprints (American Chemical Society, Division of Polymer Chemistry), 48, 1005-1006, 2007.


    Glazer, M.I., Fidanza, J.A., McGall, G.H., Trulson, M.O., Forman, J.E., Frank, C.W.; “Kinetics of Oligonucleotide Hybridization to DNA Probe Arrays on High-Capacity Porous Silica Substrates,” Biophysical Journal, 93, 1661-1676, 2007.


    Stalgren, J.J.R., Botschkova, K., Ericsson, J.-C., Frank, C.W., Knoll, W., Satija, S., Toney, M.F.; “Enrichment of Deuterium Oxide at Hydrophilic Interfaces in Aqueous Solutions,” Langmuir, 23, 11943-11946, 2007.


    Shen, Y., Powell, R. L., Longo, M. L.; “Interfacial and Stability Study of Microbubbles Coated with a Monostearin/Monopalmitin-Rich Food Emulsifier and PEG40 Stearate”, Journal of Colloid and Interface Science, 321, 186–194, 2008.


    Lee, J.S., Dylla-Spears, R., Teclemariam, N.P., Muller, S.J.; “Microfluidic Four-Roll Mill for all Flow Types”. Applied Physics Letters, 90, 074103, 2007.

    Kasson, P., Pande, V. S.; “Ensemble Molecular Dynamics Simulation Predicts Membrane Fusion Mechanism Controlled by Lipid Composition”. PloS Computational Biology, 3, 220, 2007


    Kasson. P., Zomorodian, A., Park, S., Singhal, N., Guibas, L., Pande, V. S.; “Persistent Voids: a New Structural Metric for Membrane Fusion”. Bioinformatics, 23, 1753-9, 2007.


    Lee, J.S., Shaqfeh, E.S.G., Muller, S.J.; “Dynamics of DNA Tumbling in Shear to Rotational Mixed Flows: Pathways and Periods”. Phys. Rev. E., 75, 040802(R), 2007.


    Teixeira, R., Dambal, A.K., Richter, D.H., Shaqfeh, E.S.G., Chu, S.; “The Individualistic Dynamics of Entangled DNA in Solution”. Macromolecules, 40, 7, 2461-2476, 2007.


  7. Myung, D., Koh, W., Bakri, A., et al; “Design and Fabrication of an Artificial Cornea Based on a Photolithographically Patterned Hydrogel Construct”. Biomedical Microdevices, 9, 911-922, 2007.

    Myung, D., Koh, W., Ko, J., Hu, Y., Carrasco, M., Noolandi, J., Ta, C.N., Frank, C.W. ; “Biomimetic Strain Hardening in Interpenetrating Network Hydrogels”. Polymer 18, 53776-5387, 2007.


    Myung, D., Farooqui, N., Waters, D., Schaber, S., Koh, W., Carrasco, M., Noolandi, J., Frank, C.W., Ta, C.N.; “Glucose-Permeable Interpenetrating Polymer Network Hydrogels for Corneal Transplant Applications: A Pilot Study”. Current Eye Research, 33, 29-43, 2008.


    Jang, S.S., Goddard, III, W.A., Kalani, M.Y.S., Myung, D., Frank, C.W.; “Mechanical and Transport Properties of the Poly(ethylene oxide)-Poly(acrylic acid) Double Network Hydrogel from Molecular Dynamic Simulations”. J. Physical Chemistry B, 111, 14440-14440, 2007.


    Reiser, K. M., Bratton, C., Yankelevich, D. R., Knoesen, A., Rocha-Mendoza, I., Lotz. J.; “Quantitative Analysis of Structural Disorder in Intervertebral Disks Using Second Harmonic Generation Imaging Comparison with Morphometric Analysis”. Journal of Biomedical Optics, 12, 6, 064019/1-17, 2007.


  8. Yuan, Q., Mannsfeld, S. C. B., Tang, M., Toney, M. F., Luning, J., Bao, Z.; “Thin Film Structure of Tetraceno[2,3-b]thiophene Characterized by Grazing Incidence X-ray Scattering and Near-Edge X-ray Absorption Fine Structure Analysis”. J. Am. Chem. Soc., 130, 3502-358, 2008.

    Liu, S., Mannsfeld, S. C. B., LeMieux, M. C. H., Lee, W., Bao, Z.; “Organic Semiconductor-Carbon Nanotube Bundle Bilayer Field Effect Transistors with Enhanced Mobilities and High On/Off Ratios”. Appl. Phys. Lett., 92, 053306, 2008.

    Oh, J. H., Schmidt, R., Liu, S., Würthner, F., Bao, Z.; “Air-Stable n-Channel Organic Thin-Film Transistors With High Field-Effect Mobility Based on N,N¢-bis(heptafluorobutyl)-3,4:9,10-Perylene Diimide”. Appl. Phys. Lett. 91, 07, 2007.


    Ling, M. M., Erk, P., Gomez, M., Koenemann, M., Locklin, J., Bao, Z.; “Air-Stable n-Channel Organic Semiconductors Base on Perylene Diimide Derivatives Without Strong Electron Withdrawing Groups”. Adv. Mater., 19, 1123-1127, 2007.

    Ling, M. M., Bao, Z.; “Complementary Inverter Using High Mobility Air-Stable Perylene Diimide Derivatives”. Appl. Phys. Lett., 90, 093508, 2007.


    Liu, S., Briseno, A., Mannsfeld, S. C. B., Locklin, J., You, W., Lee, H., Xia, Y., Bao, Z.; “Selective Crystallization of Organic Semiconductors on Patterned Templates of Carbon Nanotubes”. Adv. Func. Mater. 17, 2891-2896, 2007.


    Reese, C., Bao, Z.; “High Angular Resolution Measurement of the Anisotropy of Charge Transport in Single Crystals”. Adv. Mater. 19, 4535-4538, 2007. (Featured in Materials View).

    Liu, S., Wang, W., Mannsfeld, S. C. B., Locklin, J., Erk, P., Gomez, M., Richer, F., Bao, Z.; “Solution-Assisted Assembly of Organic Semiconducting Single Crystals on Surfaces with Patterned Wettability”. Langmuir, 23, 7428-7432, 2007.


    Fujiwara, T, Locklin J, Bao, Z.; “Solution Deposited Liquid Crystalline Semiconductors on a Photoalignment Layer for Organic Thin-Film Transistors”. Appl. Phys. Lett. 90, 232108, 2007.


    Schmidt, R., Ling, M.M., Oh, J.H. Winkler, M.; Könemann, M., Bao, Z., Würthner, F.; “Core-Fluorinated Perylene Bisimide Dyes: Air Stable n-Channel Organic Semiconductors for Thin Film Transistors with Exceptionally High on-to-Off Current Ratios”. Adv. Mater. 19, 3692-3695, 2007.

    Ling, M.M., Reese, C., Briseno, A. L., Bao, Z.; “Probing the Anisotropy of Charge Carrier Mobility in the Tetracene Single Crystal”. Syn. Met., 157, 257-260, 2007.

    Sung, A., Ling, M.M., Tang, M.L., Bao, Z., Locklin, J.; “Correlating Molecular Structure to Field-Effect Mobility: The Investigation of Side-Chain Functionality in Phenylene - Thiophene Oligomers and Their Application in Field Effect Transistors”. Chem. Mater. 19, 2342-2351, 2007.

    Okamoto, T., Senatore, M.L., Ling, M.M., Mallik, A.B., Tang, M.L., Bao, Z.; “Synthesis, Characterization, and Thin Film Transistor Performance of Pentacene Derivatives”. Adv. Mater., 19, 3381-3384, 2007.


    Chen, H.Z., Ling, M.M., Mo, X., Shi, M.M., Bao, Z.; “Air Stable n-Channel Organic Semiconductors for Thin Film Transistors Based on Fluorinated Derivatives of Perylene Diimides”. Chem. Mater., 19, 816-824, 2007.


    Reese, C., Bao, Z.; “Organic Single-Crystal Field-Effect Transistors”. Mater. Today, 10, 20-27, 2007.


    Cho, N.J., Cheong, K.H., Lee, C.H., Frank, C.W., Glenn, J.S.; “Binding Dynamics of Hepatitus C. Virus’ NS5A Amphipathic Peptide to Cell and Model Membranes”. Journal of Virology, 81, 6682-6689, 2007.


    Cho, N.J., Cho, S.J., Cheong, K.H., Glenn, J.S., Frank, C.W.; “Employing an Amphipathic Viral Peptide to Create a Lipid Bilayer on Au and TiO2”. J. American Chemical Society, 129, 10050-10051, 2007.


    Cho, N.J., Kanazawa, K.K., Glenn, J.S., Frank, C.W.; “Employing Two Different Quartz Crystal Microbalance Models to Study Changes in Viscoelastic Behavior Upon Transformation of Lipid Vesicles to a Bilayer on a Gold Surface”. Analytical Chemistry, 79, 7027-7035, 2007.

    Cho, N.J., Cho, S.J., Hardesty, J.O., Glenn, J.S., Frank, C.W.; “Creation of Lipid Partitions by Deposition of Amphipathic Viral Peptides”. Langmuir, 23, 10855-10863, 2007.